(Or OUR LADY OF PERPETUAL HELP.)
It represents the Mother of God holding the Divine Child while the Archangels Michael and Gabriel present before Him the instruments of His Passion. Over the figures in the picture are some Greek letters which form the abbreviated words Mother of God, Jesus Christ, Archangel Michael, and Archangel Gabriel respectively. It was brought to Rome towards the end of the fifteenth century by a pious merchant, who, dying there, ordered by his will that the picture should be exposed in a church for public veneration. It was exposed in the church of San Matteo, Via Merulana, between St. Mary Major and St. John Lateran. Crowds flocked to this church, and for nearly three hundred years many graces were obtained through the intercession of the Blessed Virgin. The picture was then popularly called the Madonna di San Matteo. The church was served for a time by the Hermits of St. Augustine, who had sheltered their Irish brethren in their distress. These Augustinians were still in charge when the French invaded Rome (1812) and destroyed the church. The picture disappeared; it remained hidden and neglected for over forty years, but a series of providential circumstances between 1863 and 1865 led to its discovery in an oratory of the Augustinian Fathers at Santa Maria in Posterula. *Catholic Encyclopedia
O Mother of Perpetual Help, grant that I may ever invoke thy most powerful name, which is the safeguard of the living and the salvation of the dying. O Purest Mary, O Sweetest Mary, let thy name henceforth be ever on my lips. Delay not, O Blessed Lady, to help me whenever I call on thee, for, in all my needs, in all my temptations I shall never cease to call on thee, ever repeating thy sacred name, Mary, Mary.